PRF: Platelet Rich Fibrin

 
 

Platelet Rich Fibrin is the new generation of PRP (platelet Rich Plasma).

The new and improved version contains no chemicals or additives like PRP with the anticoagulant use in the blood draw tube. It also contains a fibrin matrix that increases collagen and elastin production in the skin.

Treatment

PRF will show the best results if 1 treatment is performed every 2-3 weeks for a round of 3 treatments.

This can be repeated annually as a maintenance practice.

PRF can be applied to the skin of the face, neck, décolleté, the hands or anywhere that is showing signs of aging.

PRF can also be used to assist in hair growth when injected into the scalp.

Collection Process

Platelet-rich fibrin (PRF) is collected through a simple and minimally invasive procedure. Here are the general steps involved in the collection of PRF:

  1. Patient Blood Draw:

    • A small amount of the patient's blood is drawn, typically from a peripheral vein, such as the arm.

  2. Blood Centrifugation:

    • The collected blood is then processed in a centrifuge machine. Unlike other platelet-rich products, PRF is typically prepared without the use of anticoagulants.

  3. Centrifugation Process:

    • The centrifuge machine spins the blood at a specific speed and duration. This process separates the blood into its individual components based on their density.

  4. Formation of PRF Layers:

    • After centrifugation, the blood separates into three distinct layers:

      • The bottom layer contains red blood cells.

      • The middle layer consists of a fibrin clot enriched with platelets and leukocytes. This layer is the platelet-rich fibrin (PRF).

      • The top layer is platelet-poor plasma.

  5. Collection of PRF:

    • The middle layer, which is the PRF clot, is carefully collected using sterile instruments. This PRF clot contains a concentrated amount of platelets, leukocytes, and growth factors embedded in a fibrin matrix.

PRF VS PRP

Platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) are both autologous blood-derived products that contain a concentrated amount of platelets, growth factors, and other bioactive proteins. However, there are differences in their preparation, composition, and applications.

  1. Platelet-Rich Fibrin (PRF):

    • Preparation: PRF is prepared by centrifuging a blood sample without anticoagulants. The centrifugation process separates the blood into three layers: the bottom layer contains red blood cells, the middle layer is the PRF clot, and the top layer consists of platelet-poor plasma.

    • Composition: PRF contains a three-dimensional fibrin matrix that traps platelets, leukocytes, and some growth factors. The fibrin matrix provides a scaffold that supports cell migration, proliferation, and tissue healing.

  2. Platelet-Rich Plasma (PRP):

    • Preparation: PRP is prepared by centrifuging a blood sample with anticoagulants, separating it into plasma and cellular components. The plasma, rich in platelets, is collected for use.

    • Composition: PRP contains a higher concentration of platelets compared to whole blood, along with growth factors. However, it lacks the fibrin matrix present in PRF.

Therefore PRF is an ALL NATURAL treatment with no additives and a fibrin matrix that create collagen type 1 factor that helps to create elastin and collagen in the skin.